放射線影響に関する論文等の一部紹介
放射線の研究は歴史的背景から防護に関する観点で注目されるため敬遠さ れがちですが、キュリー夫人を始めとして、エネルギーの生物影響として 放射線の研究は多くの国や地域で行われてきました。また、欧州に点在す る多くの伝統的な自然療法の自然科学的解釈は、エネルギー療法として理 解されています。従って、一部の国ではラドン温泉など低放射線による生 物影響が治療効果を示す事から治療行為として行われているのです。また、 古代ローマ時代より療養泉として経験的に活用されてきた温泉の中 には、高濃度にラドンを含むものもが多い事が近年明らかにされ てきています。
テーマ別論文の紹介
1) がん;
1-1) Cancer immunotherapy: how low level ionizing radiation can play a key role. Janiak MK, Wincenciak M・ Aneta Cheda A, et al. Cancer Immunol Immunother., 2017; DOI 10.1007/s00262-017-1993-z
1-2) Adjuvant therapy for resected exocrine pancreatic cancer by half-body low-dose irradiation. Cuttler J, Garzon P, Mitchel RE, et al. J Cancer Clin Trials, 2016
1-3) Reduced ovarian cancer incidence in women exposed to low dose ionizingbackground radiation or radiation to the ovaries after treatment for breast cancer or rectosigmoid cancer. Lehrer S, Sheryl Green S and Rosenzweig KE. Asian Pac J Cancer Prev., 2016
1-4) Low-dose radiation induces cell proliferation in human embryonic lung fibroblasts but not in lung cancer cells: importance of ERK1/2 and AKT signaling pathways. Liang X, Gu J, Yu D, et al. Dose-Response ,2016.
1-5) Effects of cobalt-60 exposure on health of Taiwan residents suggest new approachneeded in radiation protection. Chen WL, Luan YC, Shieh ST, et al. Dose-Response, 2007.
1-6) Regression of non-irradiated metastases after extra cranial stereotactic radiotherapyin metastatic renal cell carcinoma. Wersall PJ, Blomgren H, Pisa P, et al. Acta Oncologica, 2006.
2. 炎症;
2-1) Study of antioxidative effects and anti-inflammatory effects in mice due to low-dose Xirradiation or radon inhalation. Kataoka T. J Radiat Res., 2013
2-2) Low-dose gamma-irradiation inhibits IL-6 secretion from human lung fibroblasts that promotes bronchial epithelial cell transformation by cigarette-smoke. Chen W, Xu X, Bai L, et al. Carcinogenesis, 2012.
2-3) Immunomodulatory properties and molecular effects in inflammatory diseases of lowdose X-irradiation. Rodel R, Frey B, Manda K, et al. Frontiers in Oncol., 2012.
3. 糖尿病;
3-1) Low-dose radiation prevents type 1 diabetes-induced cardiomyopathy via activation of AKT mediated anti-apoptotic and anti-oxidant effects. Zhang F, Xiufei Lin X, Yu L, et al. J Cell Mol Med., 2016.
3-2) Multiple low-dose radiation prevents type 2 diabetes-induced renal damage through attenuation of dyslipidemia and insulin resistance and subsequent renal inflammation and oxidative stress. Shao M, Lu X, Cong W, et al. PLOS ONE, 2014.
4.神経疾患;
4-1) Treatment of Alzheimer disease with CT scans: a case report Cuttler JM, Moore ER, Hosfeld VD, et al. Dose-Response, DOI.
4-2) Low-dose-rate, low-dose irradiation delays neurodegeneration in a model of retinitis pigmentosa. Otani A, Kojima H, Guo G, et al. Am J Pathol., 2012.
5. 免疫疾患
5-1) Hormetic response to low-dose Radiation: focus on the immune system and its clinical implications. Jiuwei Cui , Guozi Yang , Zhenyu Pan, et al. Int. J. Mol. Sci., 2017.
5-2) Low-dose radiation therapy of cancer: role of immune enhancement. Farooque A, Mathur R, Verma A, et al. Expert Rev. Anticancer Ther., 2011.
5-3) Cancer control related to stimulation of immunity by low-dose radiation. Liu SZ. Dose-Respose, 2006.
6. その他
6-1) Radiation-hormesis phenotypes, the related mechanisms and implications for disease prevention and therapy. Scott BR. J Cell Commun Signal., 2014.
6-2) The Therapeutic use of Radon: a biomedical treatment in Europe; An alternative remedy in the United STATES. Erickson BE. Dose-Response, 2007.
ヤーヒモフ温泉病院のエントランスに 掲げられているキュリー夫人の写真